Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL66292 | 0.86 | ALDH1A1 (0.35) | ALDH1A1MAPT | |
| SCHEMBL64675 | 0.82 | PDK1 (0.38) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL66854 | 0.81 | CHRM2 (0.38) | PDK1PDK2PDK3PDK4ELANE | |
| SCHEMBL78622 | 0.80 | SMN1; SMN2 (0.38) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL78407 | 0.77 | PDK1 (0.37) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL78189 | 0.76 | PDK1 (0.38) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL4399041 | 0.75 | TMEM97 (0.45) | L3MBTL1TSHR | |
| SCHEMBL78327 | 0.74 | PDK1 (0.40) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL34466974 | 0.74 | PREP (0.42) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL30781571 | 0.74 | PREP (0.42) | PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |