Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65367 | 0.89 | REN (0.38) | RENCYP3A4 | |
| SCHEMBL91368 | 0.88 | REN (0.51) | RENCYP3A4 | |
| SCHEMBL91260 | 0.82 | PPARA (0.35) | — | |
| SCHEMBL64604 | 0.77 | REN (0.52) | RENCYP3A4 | |
| SCHEMBL65084 | 0.77 | REN (0.37) | RENCYP3A4 | |
| SCHEMBL91259 | 0.76 | HTR2C (0.33) | — | |
| SCHEMBL91348 | 0.74 | REN (0.50) | RENCYP3A4 | |
| SCHEMBL8264237 | 0.74 | REN (0.45) | RENCYP3A4 | |
| SCHEMBL8265425 | 0.71 | REN (0.46) | RENCYP3A4 | |
| SCHEMBL8263352 | 0.70 | CYP3A4 (0.45) | RENCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |