Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91259 | 0.87 | HTR2C (0.33) | MGLLHTR2CPDK1PDK2PDK3 | |
| SCHEMBL65202 | 0.85 | MGLL (0.36) | PPARAMGLLHTR2CPDK1PDK2 | |
| SCHEMBL91190 | 0.82 | REN (0.38) | — | |
| SCHEMBL10289009 | 0.82 | PARP1 (0.38) | PPARAPDK1PDK2PDK3PDK4 | |
| SCHEMBL14420341 | 0.80 | HTR2C (0.41) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL65231 | 0.78 | CHRM5 (0.39) | MGLLPDK1PDK2PDK3PDK4 | |
| SCHEMBL78635 | 0.77 | PDK1 (0.35) | MGLLHTR2CPDK1PDK2PDK3 | |
| SCHEMBL91250 | 0.77 | PARP1 (0.34) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL91298 | 0.76 | CHRM5 (0.37) | PPARAHTR2CPDK1PDK2PDK3 | |
| SCHEMBL14420257 | 0.73 | POLB (0.48) | HTR2CPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |