Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 6/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | TDP2 | O95551 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIR | O00625 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13617231 | 0.92 | PNMT (0.41) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL10238388 | 0.82 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL29989368 | 0.75 | MAPT (0.40) | PIK3CDHTR6PRMT5WDR77 | |
| SCHEMBL9122886 | 0.75 | CA1 (0.39) | PIK3CDHTR6 | |
| SCHEMBL31246225 | 0.75 | CA1 (0.39) | PIK3CDHTR6 | |
| SCHEMBL29790845 | 0.75 | PNMT (0.46) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL4523516 | 0.75 | PNMT (0.46) | PNMTADRA2AADRA2BADRA2CTDP2 | |
| SCHEMBL19023151 | 0.75 | DRD2 (0.43) | — | |
| SCHEMBL8237889 | 0.75 | PIK3CD (0.36) | ADRA2APIK3CDPIR | |
| SCHEMBL9125380 | 0.75 | HTR2A (0.48) | PNMTADRA2AADRA2BADRA2CPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021048567-A1 | NEW COMPOUNDS AND METHODS | BENEVOLENTAI BIO LIMITED (GB) | 2021-03-18 | — | — | WO | disclosed |
| US-5395827-A | Analgesic, anticonvulsant, antiepileptic and anxiolytic agents | GUILFORD PHARMACEUTICALS INC. (US) | 1995-03-07 | — | — | US | disclosed |
| US-5364876-A | Tranquilizers, analgesics, learning enhancement | GUILFORD PHARMACEUTICALS INC. (US) | 1994-11-15 | — | — | US | disclosed |
| WO-1993005772-A1 | φ-[2-(PHOSPHONOALKYL)PHENYL]-2-AMINOALKANOIC ACIDS AS ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS | NOVA PHARMACEUTICAL CORPORATION (US) | 1993-04-01 | — | — | WO | disclosed |