Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GALR1 | P47211 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119298 | 0.81 | PTGS2 (0.38) | PTGS1PTGS2HPGDALDH1A1LMNA | |
| SCHEMBL5030910 | 0.81 | PTGS2 (0.40) | PTGS1PTGS2HPGDALDH1A1 | |
| SCHEMBL9117197 | 0.80 | PLCG1 (0.37) | CA2PTGS2NPC1ALDH1A1LMNA | |
| SCHEMBL9118988 | 0.80 | PTGS2 (0.45) | PTGS1PTGS2POLBALDH1A1LMNA | |
| SCHEMBL8776835 | 0.80 | PTGS2 (0.45) | PTGS1PTGS2NR3C1 | |
| SCHEMBL9118873 | 0.77 | PTGS2 (0.42) | CA2PTGS1PTGS2 | |
| SCHEMBL9116829 | 0.76 | PTGS2 (0.43) | CA2PTGS2MAPT | |
| SCHEMBL3994708 | 0.74 | TP53 (0.38) | EGFRUCHL1TP53GALR1NPC1 | |
| SCHEMBL6930665 | 0.72 | PTGS2 (0.36) | PTGS1PTGS2 | |
| SCHEMBL3057707 | 0.72 | KEAP1 (0.40) | PTGS2L3MBTL1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |