Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 5/20 | 0.64 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.64 |
| ▸ | PPARG | P37231 | 8/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9121396 | 0.89 | AGTR1 (0.58) | AGTR1AGTR2PPARGPOLB | |
| SCHEMBL5864485 | 0.87 | AGTR1 (0.53) | AGTR1AGTR2PPARG | |
| SCHEMBL6777744 | 0.82 | TBXA2R (0.52) | — | |
| SCHEMBL5864446 | 0.82 | AGTR1 (0.48) | AGTR1AGTR2PPARG | |
| SCHEMBL8411049 | 0.81 | USP2 (0.55) | POLB | |
| SCHEMBL9192299 | 0.78 | AGTR1 (1.00) | AGTR1AGTR2PPARGPOLB | |
| SCHEMBL5864383 | 0.78 | PDE6D (0.51) | — | |
| SCHEMBL9434830 | 0.76 | AGTR1 (0.66) | AGTR1AGTR2PPARGPOLBLMNA | |
| SCHEMBL8396958 | 0.75 | PPARG (1.00) | AGTR1AGTR2PPARG | |
| SCHEMBL8976741 | 0.75 | AGTR1 (0.59) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5451583-A | Angiotensin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-09-19 | — | — | US | claimed |
| US-5451583-A | Angiotensin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| WO-1994011365-A1 | SUBSTITUTED BENZIMIDAZOLES AND QUINAZOLINES AS ANTIHYPERTENSIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-05-26 | — | — | WO | disclosed |
| US-5283242-A | Hypotensive agents, cardiotonic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-02-01 | — | — | US | disclosed |