Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 6/20 | 0.44 |
| ▸ | HTR3A | P46098 | 7/20 | 0.43 |
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | HTR7 | P34969 | 5/20 | 0.43 |
| ▸ | HTR2B | P41595 | 5/20 | 0.43 |
| ▸ | HTR6 | P50406 | 5/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | HTR5A | P47898 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.42 |
| ▸ | HTR3B | O95264 | 3/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9121582 | 0.82 | HTR7 (0.47) | HTR3AHTR1AHTR7HTR2BHTR6 | |
| SCHEMBL2545151 | 0.73 | HTR6 (0.47) | ADRB1HTR1AHTR7HTR2BHTR6 | |
| SCHEMBL29831886 | 0.70 | HTR3A (0.60) | ADRB1HTR3AHTR1AHTR7HTR2B | |
| SCHEMBL232523 | 0.70 | HTR3A (0.60) | ADRB1HTR3AHTR1AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL1904530 | 0.68 | HTR3A (0.61) | ADRB1HTR3AHTR1AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL4480506 | 0.68 | HTR3A (0.61) | ADRB1HTR3AHTR1AHTR7HTR2B | |
| Piperazine SCHEMBL28188812 | 0.68 | HTR3A (0.58) | ADRB1HTR3AHTR1AHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL31322444 | 0.68 | HTR3A (0.61) | ADRB1HTR3AHTR1AHTR7HTR2B | |
| SCHEMBL9119205 | 0.68 | ADRB1 (0.49) | ADRB1HTR3AHTR1AHTR7HTR6 | |
| SCHEMBL234944 | 0.66 | HTR3A (0.55) | ADRB1HTR3AHTR1AHTR7HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189612-B1 | NEW PHARMACEUTICAL COMPOSITIONS HAVING A PSYCHOTROPIC ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1992-11-04 | — | — | EP | claimed |
| EP-0189612-A1 | New pharmaceutical compositions having a psychotropic activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1986-08-06 | — | — | EP | claimed |
| US-5424313-A | Bibyclic heteroacrylpiperazine derivatives having psychotropic activity, and pharmaceutical compositions containing these derivatives | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1995-06-13 | — | — | US | disclosed |
| EP-0189612-B1 | NEW PHARMACEUTICAL COMPOSITIONS HAVING A PSYCHOTROPIC ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1992-11-04 | — | — | EP | disclosed |
| EP-0189612-A1 | New pharmaceutical compositions having a psychotropic activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1986-08-06 | — | — | EP | disclosed |