Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | SOD1 | P00441 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL322457 | 0.86 | KDM4E (0.50) | TSHRMAPK1L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL9326234 | 0.83 | TAAR1 (0.53) | TSHRMAPK1L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL11162901 | 0.83 | GPBAR1 (0.50) | TSHRMAPK1L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL9122825 | 0.83 | LMNA (0.59) | TSHRMAPK1L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL12648147 | 0.81 | KDM4E (0.48) | TSHRMAPK1L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL20201962 | 0.81 | ALDH1A1 (0.49) | TSHRMAPK1L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL17277359 | 0.80 | SCN4A (0.50) | TSHRMAPK1L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL17277505 | 0.80 | SCN4A (0.50) | TSHRMAPK1L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL19944724 | 0.79 | KDM4E (0.49) | TSHRMAPK1L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL9121666 | 0.79 | ADRB2 (0.56) | L3MBTL1SMN1; SMN2DRD2DRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0492615-B1 | Process for producing biguanide derivative | IDEMITSU KOSAN CO (JP) | 1995-03-08 | — | — | EP | disclosed |
| US-5286905-A | Heating hydrogen halide salt of phenoxyalkylamine with dicyandiamide in paraffinic hydrocarbon solvent | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1994-02-15 | — | — | US | disclosed |
| EP-0492615-A1 | Process for producing biguanide derivative | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1992-07-01 | — | — | EP | disclosed |