Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9123531 | 0.84 | HTR1A (0.49) | HTR1AADRA2ASLC6A2SLC6A4MEN1 | |
| SCHEMBL9122214 | 0.80 | HTR1A (0.50) | HTR1AADRA2ASLC6A2SLC6A4MEN1 | |
| SCHEMBL9121087 | 0.79 | KCNH2 (0.51) | MEN1KMT2ALMNAMAPTLTA4H | |
| SCHEMBL8371199 | 0.77 | HTR1A (0.49) | HTR1AADRA2ASLC6A2SLC6A4MEN1 | |
| SCHEMBL7524073 | 0.76 | HTR1A (0.52) | HTR1AADRA2ASLC6A2SLC6A4KMT2A | |
| SCHEMBL8317904 | 0.74 | HTR1A (0.51) | HTR1AADRA2ASLC6A2SLC6A4MEN1 | |
| SCHEMBL7524020 | 0.74 | HTR1A (0.51) | HTR1AADRA2ASLC6A2SLC6A4MEN1 | |
| SCHEMBL7524469 | 0.74 | HTR1A (0.51) | HTR1AADRA2ASLC6A2SLC6A4MEN1 | |
| SCHEMBL9120164 | 0.74 | HTR1A (0.49) | HTR1AADRA2ASLC6A2SLC6A4LMNA | |
| SCHEMBL201784 | 0.73 | MEN1 (0.59) | MEN1KMT2ALMNAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389668-A | Thiochroman compounds | ADIR ET COMPAGNIE (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5385930-A | Treating central nervous system disorders like anxiety and depression | ADIR ET COMPAGNIE (FR) | 1995-01-31 | — | — | US | disclosed |
| US-5371103-A | Thiochroman compounds | ADIR ET COMPAGNIE (FR) | 1994-12-06 | — | — | US | disclosed |
| US-5332741-A | Antidepressants | ADIR ET COMPAGNIE (FR) | 1994-07-26 | — | — | US | disclosed |