Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10370934 | 0.87 | MAPT (0.42) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL4266745 | 0.87 | ALDH1A1 (0.47) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL4264033 | 0.78 | SMN1; SMN2 (0.43) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL9125723 | 0.77 | TSHR (0.50) | NPC1KMT2AALDH1A1MAOBCYP3A4 | |
| SCHEMBL10477945 | 0.76 | CYP1A2 (0.54) | KMT2AALDH1A1TDP1CYP1A2TSHR | |
| SCHEMBL9123812 | 0.76 | ALDH1A1 (0.36) | NPC1RAB9ASMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL9124733 | 0.75 | ALDH1A1 (0.38) | SMN1; SMN2KMT2AALDH1A1TDP1CYP1A2 | |
| SCHEMBL9125178 | 0.73 | NPC1 (0.37) | NPC1RAB9AKMT2ACYP3A4CYP2D6 | |
| SCHEMBL9126222 | 0.73 | TDP1 (0.51) | KMT2AALDH1A1CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL28569559 | 0.72 | SMN1; SMN2 (0.51) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5413997-A | For treatment of osteoporosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-05-09 | — | — | US | disclosed |
| EP-0395093-B1 | TRIPHENYLMETHANE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-01 | — | — | EP | disclosed |
| US-5112867-A | Osteoporosis Treatment | KYOWA HAKKO GOGYO CO., LTD. (JP) | 1992-05-12 | — | — | US | disclosed |