Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.48 |
| ▸ | PPIF | P30405 | 1/20 | 0.43 |
| ▸ | PPIA | P62937 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9129017 | 0.93 | SGMS2 (0.50) | SGMS2PPIFPPIAALDH1A1KDM4E | |
| SCHEMBL9127827 | 0.92 | PPIA (0.50) | SGMS2PPIFPPIAALDH1A1TDP1 | |
| SCHEMBL9126729 | 0.91 | SGMS2 (0.55) | SGMS2PPIFPPIATDP1DHODH | |
| SCHEMBL9125275 | 0.88 | PPIF (0.49) | SGMS2PPIFPPIAALDH1A1KDM4E | |
| SCHEMBL9124032 | 0.86 | PPIA (0.53) | SGMS2PPIFPPIAALDH1A1SMN1; SMN2 | |
| SCHEMBL9126946 | 0.86 | PPIA (0.53) | SGMS2PPIFPPIAALDH1A1MAPK1 | |
| SCHEMBL9129421 | 0.85 | PPIF (0.55) | SGMS2PPIFPPIAALDH1A1KDM4E | |
| SCHEMBL9127894 | 0.84 | PPIA (0.55) | SGMS2PPIFPPIAALDH1A1TDP1 | |
| SCHEMBL9126609 | 0.83 | PPIA (0.53) | SGMS2PPIFPPIA | |
| SCHEMBL9126126 | 0.83 | PPIF (0.47) | SGMS2PPIFPPIAALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5409943-A | [(alkoxy)pyridinyl]amine compounds which are useful in the treatment of gastrointestinal disorders | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1995-04-25 | — | — | US | disclosed |
| EP-0625143-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015055-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | disclosed |