Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 11/20 | 0.53 |
| ▸ | PPIF | P30405 | 2/20 | 0.49 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9127827 | 0.95 | PPIA (0.50) | PPIAPPIFSGMS2RAB9ACNR1 | |
| SCHEMBL9128706 | 0.92 | PPIA (0.52) | PPIAPPIFSGMS2RAB9ANPC1 | |
| SCHEMBL9129017 | 0.89 | SGMS2 (0.50) | PPIAPPIFSGMS2RAB9ASMN1; SMN2 | |
| SCHEMBL9127894 | 0.89 | PPIA (0.55) | PPIAPPIFSGMS2RAB9ANPC1 | |
| SCHEMBL9126729 | 0.87 | SGMS2 (0.55) | PPIAPPIFSGMS2RAB9A | |
| SCHEMBL9125551 | 0.87 | PPIA (0.53) | PPIAPPIFSGMS2RAB9ASMN1; SMN2 | |
| SCHEMBL9123957 | 0.86 | SGMS2 (0.48) | PPIAPPIFSGMS2RAB9ASMN1; SMN2 | |
| SCHEMBL9125346 | 0.84 | PPIA (0.50) | PPIAPPIFSGMS2RAB9ANPC1 | |
| SCHEMBL9357599 | 0.84 | PPIA (0.50) | PPIAPPIFSGMS2RAB9ACNR1 | |
| SCHEMBL9124706 | 0.84 | PPIA (0.50) | PPIAPPIFSGMS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625143-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | claimed |
| WO-1993015055-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | claimed |
| US-5409943-A | [(alkoxy)pyridinyl]amine compounds which are useful in the treatment of gastrointestinal disorders | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1995-04-25 | — | — | US | disclosed |
| EP-0625143-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015055-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | disclosed |