Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 6/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9125512 | 0.84 | SYK (0.37) | VCAM1PTGS1PTGS2ALDH1A1GAA | |
| SCHEMBL9841876 | 0.81 | ALDH1A1 (0.40) | PTGS1PTGS2ALDH1A1GAATDP1 | |
| SCHEMBL9123205 | 0.79 | RAB9A (0.41) | GAA | |
| SCHEMBL9122485 | 0.78 | BACE1 (0.38) | ALDH1A1GAA | |
| SCHEMBL9831339 | 0.77 | SYK (0.33) | PTGS1PTGS2 | |
| Acetic Acid Phenyl Ester SCHEMBL9123392 | 0.75 | MAPT (0.39) | PTGS1PTGS2ALDH1A1GAATDP1 | |
| SCHEMBL9830610 | 0.74 | WNT3A (0.39) | PTGS1PTGS2TDP1MAPK8 | |
| SCHEMBL9123013 | 0.73 | NPC1 (0.42) | ALDH1A1GAATDP1NR1H4 | |
| SCHEMBL9123927 | 0.73 | MKNK1 (0.39) | — | |
| SCHEMBL9122090 | 0.73 | ALDH1A1 (0.36) | VCAM1PTGS1PTGS2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0425650-A1 | ANTI-INFLAMMATORY 4-AMINOPHENOL DERIVATIVES. | FISONS PLC (GB) | 1991-05-08 | — | — | EP | claimed |
| WO-1990014338-A1 | ANTI-INFLAMMATORY 4-AMINOPHENOL DERIVATIVES | FISONS PLC (GB) | 1990-11-29 | — | — | WO | claimed |
| US-5428044-A | Anti-inflammatory 4-aminophenyl derivatives | FISONS PLC (GB) | 1995-06-27 | — | — | US | disclosed |
| EP-0425650-A1 | ANTI-INFLAMMATORY 4-AMINOPHENOL DERIVATIVES. | FISONS PLC (GB) | 1991-05-08 | — | — | EP | disclosed |
| WO-1990014338-A1 | ANTI-INFLAMMATORY 4-AMINOPHENOL DERIVATIVES | FISONS PLC (GB) | 1990-11-29 | — | — | WO | disclosed |