SCHEMBL9124381

SCHEMBL9124381

Clc1cccc2c1C(Cl)c1ccccc1O2

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 2/20 0.50
MAOA P21397 1/20 0.44
MAOB P27338 1/20 0.44
ATM Q13315 1/20 0.38
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
HDAC9 Q9UKV0 1/20 0.36
HDAC5 Q9UQL6 1/20 0.36
CACNB4 O00305 1/20 0.36
CACNA1A O00555 1/20 0.36
CACNA1G O43497 1/20 0.36
CACNG3 O60359 1/20 0.36
CACNA1F O60840 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11728246 0.80 MAOA (0.62) AHRMAOAMAOBATMHDAC3
SCHEMBL1128327 0.80 MAOA (0.58) AHRMAOAMAOBATMHDAC3
SCHEMBL9407337 0.77 AHR (0.46) AHRMAOAMAOBATMHDAC3
SCHEMBL4298019 0.75 ATM (0.56) AHRMAOAMAOBATMHDAC3
SCHEMBL10896706 0.74 AHR (0.42) AHRMAOAMAOBATMHDAC3
Water SCHEMBL7405955 0.73 CACNB4 (0.39) AHRCACNB4CACNA1ACACNA1GCACNG3
Bromide SCHEMBL8344294 0.73 CACNB4 (0.39) AHRCACNB4CACNA1ACACNA1GCACNG3
SCHEMBL1524420 0.72 CYP2C9 (0.51) AHRMAOAMAOBATMHDAC3
SCHEMBL5606087 0.71 MAOA (0.42) AHRMAOAMAOBATMHDAC3
SCHEMBL5618043 0.71 CACNB4 (0.39) CACNB4CACNA1ACACNA1GCACNG3CACNA1F

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5387725-A Chlorinating compounds having acidic protons with a perchloro-alkane and aqueous base in the presence of a tetraalkyl-ammonium hydroxide phase transfer catalyst THE DOW CHEMICAL COMPANY (US) 1995-02-07 US claimed
US-5073176-A Permselective E. I. DU PONT DE NEMOURS AND COMPANY (US) 1991-12-17 US disclosed