Indoline

Indoline

SCHEMBL9124759

C1=Nc2ccccc2C1.c1ccc2c(c1)CCN2

nearest known ligand 0.41

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.38
HSD17B10 Q99714 1/20 0.38
DRD2 P14416 1/20 0.36
DRD4 P21917 1/20 0.36
PDPK1 O15530 1/20 0.36
PARP1 P09874 1/20 0.36
PARP10 Q53GL7 1/20 0.36
PARP11 Q9NR21 1/20 0.36
HTR2C P28335 1/20 0.35
NPC1 O15118 1/20 0.33
MAPK13 O15264 1/20 0.33
MAPK12 P53778 1/20 0.33
MAPK11 Q15759 1/20 0.33
MAPK14 Q16539 1/20 0.33
TRPA1 O75762 1/20 0.33
PNMT P11086 1/20 0.32
CD44 P16070 1/20 0.32
MAOB P27338 1/20 0.32
BCHE P06276 1/20 0.32
ACHE P22303 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indoline SCHEMBL4782846 0.83 HSD17B10 (0.44) ALOX15HSD17B10
SCHEMBL29861109 0.80
SCHEMBL60763 0.80
Indoline SCHEMBL5629 0.80
Indoline SCHEMBL29360339 0.80
Ammonia Solution, Strong SCHEMBL23326973 0.78 TRPA1 (0.43) NPC1TRPA1MAPTHPGD
Indoline SCHEMBL11401846 0.78 HTR2C (0.50) ALOX15HSD17B10DRD2DRD4PDPK1
Indoline SCHEMBL6872936 0.78 HTR2C (0.50) ALOX15HSD17B10DRD2DRD4PDPK1
Indoline SCHEMBL8194348 0.78 HTR2C (0.50) ALOX15HSD17B10DRD2DRD4PDPK1
Indoline SCHEMBL1587228 0.78 HTR2C (0.50) ALOX15HSD17B10DRD2DRD4PDPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5391741-A Can be vacuum deposited; storage stability, high absorbance in near infrared KYOWA HAKKO KOGYO CO., LTD. (JP) 1995-02-21 US disclosed