Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | BCR | P11274 | 2/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL28190149 | 0.92 | MMP3 (0.52) | RXRARXRBABL1ABCB1BCR | |
| SCHEMBL16528491 | 0.87 | ABL1 (0.46) | RXRARXRBABL1ABCB1BCR | |
| SCHEMBL11119481 | 0.85 | RXRA (0.59) | RXRARXRBMMP3BCL2L1BCL2 | |
| Biphenyl SCHEMBL27843029 | 0.81 | MMP3 (0.61) | MMP3BCL2L1EGFRTP53MEN1 | |
| SCHEMBL1689799 | 0.80 | PTGS2 (0.65) | EGFRTP53PTGS2CYP3A4ESR1 | |
| SCHEMBL597228 | 0.80 | TP53 (0.60) | RXRARXRBBCL2TP53FGFR1 | |
| SCHEMBL17954220 | 0.80 | RXRA (0.55) | RXRARXRBMMP3BCL2L1BCL2 | |
| SCHEMBL27582393 | 0.79 | RXRA (0.62) | RXRARXRBABL1ABCB1BCR | |
| Phenol SCHEMBL27612303 | 0.78 | CA12 (0.58) | RXRARXRBMMP3BCL2L1TP53 | |
| SCHEMBL125927 | 0.78 | ABL1 (0.65) | ABL1ABCB1BCRMMP3BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |