Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL9126239

N.Nc1nc2c(c(=O)[nH]1)NCN2OCOCP(=O)(O)O

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 14/20 0.65
PNP P00491 4/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9576807 0.99 HPRT1 (0.67) HPRT1PNP
SCHEMBL9417162 0.88 HPRT1 (0.72) HPRT1PNP
SCHEMBL9857606 0.86 HPRT1 (0.69) HPRT1PNP
SCHEMBL9858182 0.85 HPRT1 (0.62) HPRT1PNP
SCHEMBL8899140 0.83 HPRT1 (0.74) HPRT1PNP
SCHEMBL9417241 0.80 HPRT1 (0.74) HPRT1
SCHEMBL9684323 0.80 HPRT1 (0.62) HPRT1PNP
SCHEMBL9683454 0.79 HPRT1 (0.61) HPRT1PNP
SCHEMBL64568 0.79 HPRT1 (1.00) HPRT1PNP
SCHEMBL9685371 0.79 HPRT1 (0.54) HPRT1PNP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0494370-B1 Antiviral (phosphonomethoxy)methoxy purine/pyrimidine derivatives ACAD OF SCIENCE CZECH REPUBLIC (CS) 1995-06-28 EP disclosed
US-5386030-A Chemical intermediates INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCE OF THE CZECH REPUBLIC (CZ) 1995-01-31 US disclosed
US-5208221-A Nucleotides and intermediates for herpes virus or leukemia virus BRISTOL-MYERS SQUIBB COMPANY (US) 1993-05-04 US disclosed
EP-0494370-A1 Antiviral (phosphonomethoxy)methoxy purine/pyrimidine derivatives INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) 1992-07-15 EP disclosed