Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CETP | P11597 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9124942 | 0.83 | ALDH1A1 (0.59) | KDM4EHSD17B10ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9126492 | 0.77 | KMT2A (0.48) | KDM4EALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL9122007 | 0.74 | KMT2A (0.65) | ALDH1A1SMN1; SMN2HDAC3HDAC1HDAC2 | |
| SCHEMBL9521940 | 0.74 | EPHX2 (0.42) | KDM4EALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL9122648 | 0.74 | TDP1 (0.50) | KDM4EALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL9126018 | 0.74 | KMT2A (0.64) | KDM4EALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL8939637 | 0.73 | ALDH1A1 (0.44) | KDM4EALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL8939658 | 0.73 | ALDH1A1 (0.44) | KDM4EALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL8939608 | 0.73 | ALDH1A1 (0.44) | KDM4EALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL9125034 | 0.73 | EGFR (0.51) | SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5413997-A | For treatment of osteoporosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-05-09 | — | — | US | disclosed |
| EP-0395093-B1 | TRIPHENYLMETHANE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-01 | — | — | EP | disclosed |
| US-5112867-A | Osteoporosis Treatment | KYOWA HAKKO GOGYO CO., LTD. (JP) | 1992-05-12 | — | — | US | disclosed |
| EP-0395093-A1 | Triphenylmethane derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-10-31 | — | — | EP | disclosed |