Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8037049 | 0.81 | SMN1; SMN2 (0.37) | RENCYP3A4SMN1; SMN2HTTHSD17B10 | |
| SCHEMBL662543 | 0.79 | ALDH1A1 (0.35) | RENCYP3A4SMN1; SMN2HTTHSD17B10 | |
| SCHEMBL664034 | 0.78 | REN (0.41) | RENCYP3A4HTTALDH1A1MAPT | |
| SCHEMBL31651921 | 0.77 | GRIN2D (0.38) | L3MBTL1ALDH1A1KDM4EPTGS2 | |
| SCHEMBL78902 | 0.77 | LMNA (0.41) | RENCYP3A4L3MBTL1SMN1; SMN2HTT | |
| SCHEMBL13154804 | 0.77 | REN (0.35) | RENCYP3A4SMN1; SMN2HTTHSD17B10 | |
| SCHEMBL2635178 | 0.76 | REN (0.44) | RENCYP3A4HSD17B10DGAT2ALDH1A1 | |
| SCHEMBL665101 | 0.76 | REN (0.36) | RENCYP3A4SMN1; SMN2HTTHSD17B10 | |
| Hydrochloric Acid SCHEMBL4682923 | 0.76 | REN (0.43) | RENCYP3A4HSD17B10DGAT2ALDH1A1 | |
| SCHEMBL5141564 | 0.74 | REN (0.43) | RENCYP3A4SMN1; SMN2HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |