Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8037049 | 0.80 | SMN1; SMN2 (0.37) | LMNAHTTKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL91265 | 0.77 | REN (0.41) | HTTKDM4ESMN1; SMN2HSD17B10REN | |
| SCHEMBL13154804 | 0.76 | REN (0.35) | HTTKDM4ESMN1; SMN2HSD17B10REN | |
| SCHEMBL662543 | 0.75 | ALDH1A1 (0.35) | HTTKDM4ESMN1; SMN2HSD17B10REN | |
| SCHEMBL665101 | 0.75 | REN (0.36) | HTTKDM4ESMN1; SMN2HSD17B10REN | |
| SCHEMBL78610 | 0.72 | LMNA (0.43) | LMNAHTTMAPK1KDM4ESMN1; SMN2 | |
| SCHEMBL24650223 | 0.72 | HCAR3 (0.43) | LMNAHTTMAPK1KDM4ESMN1; SMN2 | |
| SCHEMBL9906406 | 0.70 | ALDH1A1 (0.37) | LMNAHTTMAPK1KDM4ESMN1; SMN2 | |
| SCHEMBL5141564 | 0.70 | REN (0.43) | HTTSMN1; SMN2HSD17B10RENCYP3A4 | |
| SCHEMBL13895406 | 0.69 | KCNH2 (0.44) | LMNAHTTMAPK1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |