SCHEMBL912652

SCHEMBL912652

NC(CCC[C@H](N)C(=O)O)C(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21

nearest known ligand 0.74

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 6/20 0.74
▸ MEN1 O00255 1/20 0.65
▸ ABL1 P00519 1/20 0.65
▸ LMNA P02545 1/20 0.65
▸ PKM P14618 1/20 0.65
▸ IDE P14735 1/20 0.65
▸ MAPK1 P28482 1/20 0.65
▸ KMT2A Q03164 1/20 0.65
▸ RIN1 Q13671 1/20 0.65
▸ L3MBTL1 Q9Y468 1/20 0.65
▸ HLCS P50747 6/20 0.54
▸ CA12 O43570 6/20 0.48
▸ CA1 P00915 6/20 0.48
▸ CA2 P00918 6/20 0.48
▸ CA9 Q16790 6/20 0.48
▸ FOLH1 Q04609 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15647842 0.92 TDP1 (0.77) TDP1MEN1ABL1LMNAPKM
SCHEMBL15053200 0.91 TDP1 (0.62) TDP1MEN1ABL1LMNAPKM
SCHEMBL23066879 0.91 TDP1 (0.62) TDP1MEN1ABL1LMNAPKM
SCHEMBL5091193 0.91 TDP1 (0.89) TDP1MEN1ABL1LMNAPKM
SCHEMBL629531 0.90 TDP1 (0.74) TDP1MEN1ABL1LMNAPKM
SCHEMBL2536441 0.89 TDP1 (0.62) TDP1MEN1ABL1LMNAPKM
Hydrochloric Acid SCHEMBL3417755 0.88 TDP1 (0.61) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL8011736 0.88 TDP1 (0.77) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL8011738 0.88 TDP1 (0.77) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL693036 0.87 TDP1 (0.72) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118829725-A Method for producing cells 莱尔免疫制药公司 2024-10-22 — — CN disclosed
CN-115537372-A Antigen presenting cell mimetic scaffolds and methods of making and using same 哈佛学院院长等 2022-12-30 — — CN disclosed
CN-115404196-A Antigen presenting cell mimetic scaffolds and methods of making and using same 哈佛学院院长等 2022-11-29 — — CN disclosed
CN-115305229-A Antigen presenting cell mimetic scaffolds and methods of making and using same 哈佛学院院长等 2022-11-08 — — CN disclosed
EP-3110841-B1 PEPTIDES AND METHODS OF USE BAXALTA INC (US) 2021-03-31 — — EP disclosed
US-10124033-B2 Peptides and methods of use BAXALTA INCORPORATED (US) 2018-11-13 — — US disclosed
US-10093712-B2 Immunostimulatory compositions and uses thereof SUSAVION BIOSCIENCES, INC. (US) 2018-10-09 — — US disclosed
US-20180263692-A1 DEVICES FOR DAMAGING NERVES AND RELATED METHODS OF USE BOSTON SCIENTIFIC SCIMED, INC. (US) 2018-09-20 — — US disclosed
US-20170035835-A1 PEPTIDES AND METHODS OF USE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-02-09 — — US disclosed
EP-3110841-A1 PEPTIDES AND METHODS OF USE Baxalta Incorporated (US) 2017-01-04 — — EP disclosed
WO-2005037190-A2 MULTIPLEX VACCINES DENDRITHERAPEUTICS, INC. (US) 2005-04-28 — — WO disclosed
US-20050079131-A1 Emulsion particles for imaging and therapy and methods of use thereof KEREOS, INC. 2005-04-14 — — US disclosed
WO-2005014051-A1 EMULSION PARTICLES FOR IMAGING AND THERAPY AND METHODS OF USE THEREOF BARNES-JEWISH HOSPITAL (US) 2005-02-17 — — WO disclosed
WO-2002060524-A9 ENHANCED ULTRASOUND DETECTION WITH TEMPERATURE DEPENDENT CONTRAST AGENTS BARNES JEWISH HOSPITAL (US) 2004-01-08 — — WO disclosed
EP-1363538-A2 ENHANCED ULTRASOUND DETECTION WITH TEMPERATURE DEPENDENT CONTRAST AGENTS Barnes-Jewish Hospital (US) 2003-11-26 — — EP disclosed
WO-2002060524-A2 ENHANCED ULTRASOUND DETECTION WITH TEMPERATURE DEPENDENT CONTRAST AGENTS BARNES-JEWISH HOSPITAL (US) 2002-08-08 — — WO disclosed
US-20020102216-A1 Enhanced ultrasound detection with temperature-dependent contrast agents KEREOS, INC. 2002-08-01 — — US disclosed
US-6133038-A Platinum-containing compounds methods for their preparation and applications thereof KREATECH DIAGNOSTICS (NL) 2000-10-17 — — US disclosed
US-5985566-A Platinum-containing compounds, methods for their preparation and applications thereof KREATECH DIAGNOSTICS (NL) 1999-11-16 — — US disclosed
US-5714327-A PLATINUM CONTAINING DETECTABLE PROBE COMPOUND HAVING MARKER MOIETY, STABILIZING SUBSTITUENTS, BIOMOLECULE KREATECH DIAGNOSTICS (NL) 1998-02-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050079131-A1 Emulsion particles for imaging and therapy and methods of use thereof LIPA, PHOSPHO1, PLIN3 TDP1 4341/4885MEN1 2210/4885ABL1 2290/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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