Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIF | P30405 | 1/20 | 0.44 |
| ▸ | PPIA | P62937 | 8/20 | 0.42 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.38 |
| ▸ | GUCY1B2 | O75343 | 3/20 | 0.34 |
| ▸ | GUCY1A2 | P33402 | 3/20 | 0.34 |
| ▸ | GUCY1A1 | Q02108 | 3/20 | 0.34 |
| ▸ | GUCY1B1 | Q02153 | 3/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9126603 | 0.88 | SGMS2 (0.47) | PPIFPPIASGMS2TDP1ALDH1A1 | |
| SCHEMBL9124032 | 0.81 | PPIA (0.53) | PPIFPPIASGMS2ERBB2EPHA2 | |
| SCHEMBL9125551 | 0.77 | PPIA (0.53) | PPIFPPIASGMS2ALDH1A1KMT2A | |
| SCHEMBL9357599 | 0.76 | PPIA (0.50) | PPIFPPIASGMS2ERBB2EPHA2 | |
| SCHEMBL9127827 | 0.76 | PPIA (0.50) | PPIFPPIASGMS2TDP1ALDH1A1 | |
| SCHEMBL9357595 | 0.76 | PPIF (0.46) | PPIFPPIASGMS2GUCY1B2GUCY1A2 | |
| SCHEMBL9124036 | 0.75 | PPIF (0.48) | PPIFPPIASGMS2GUCY1B2GUCY1A2 | |
| SCHEMBL9128706 | 0.74 | PPIA (0.52) | PPIFPPIASGMS2ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL9126773 | 0.73 | PPIA (0.48) | PPIFPPIA | |
| SCHEMBL9124294 | 0.72 | PPIA (0.50) | PPIFPPIASGMS2TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5409943-A | [(alkoxy)pyridinyl]amine compounds which are useful in the treatment of gastrointestinal disorders | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1995-04-25 | — | — | US | disclosed |