Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 12/20 | 0.52 |
| ▸ | PPIF | P30405 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9124032 | 0.92 | PPIA (0.53) | PPIAPPIFRAB9ANPC1SGMS2 | |
| SCHEMBL9127827 | 0.89 | PPIA (0.50) | PPIAPPIFRAB9ASGMS2SMN1; SMN2 | |
| SCHEMBL9126812 | 0.87 | PPIA (0.52) | PPIAPPIFRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9127894 | 0.85 | PPIA (0.55) | PPIAPPIFRAB9ANPC1SGMS2 | |
| SCHEMBL9129017 | 0.84 | SGMS2 (0.50) | PPIAPPIFRAB9ASGMS2SMN1; SMN2 | |
| SCHEMBL9124706 | 0.83 | PPIA (0.50) | PPIAPPIFSGMS2 | |
| SCHEMBL9125346 | 0.83 | PPIA (0.50) | PPIAPPIFRAB9ANPC1SGMS2 | |
| SCHEMBL9125073 | 0.82 | PPIA (0.75) | PPIAPPIF | |
| SCHEMBL9125096 | 0.82 | PPIA (0.51) | PPIAPPIFRAB9ANPC1TSHR | |
| SCHEMBL9126729 | 0.82 | SGMS2 (0.55) | PPIAPPIFRAB9ASGMS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5409943-A | [(alkoxy)pyridinyl]amine compounds which are useful in the treatment of gastrointestinal disorders | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1995-04-25 | — | — | US | disclosed |
| EP-0625143-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015055-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | disclosed |