Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | PPARD | Q03181 | 1/20 | 0.55 |
| ▸ | PPARA | Q07869 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10597748 | 0.86 | L3MBTL1 (0.90) | L3MBTL1MAPTTDP1PPARGPPARD | |
| SCHEMBL9117427 | 0.83 | L3MBTL1 (0.90) | L3MBTL1MAPTTDP1PPARGPPARD | |
| SCHEMBL5290069 | 0.83 | L3MBTL1 (0.69) | L3MBTL1MAPTTDP1PPARGPPARD | |
| SCHEMBL1592400 | 0.82 | DRD2 (0.72) | L3MBTL1MAPTTDP1PPARGPPARD | |
| SCHEMBL91273 | 0.81 | L3MBTL1 (0.50) | L3MBTL1MAPTTDP1PPARGCYP1A2 | |
| SCHEMBL5281663 | 0.81 | L3MBTL1 (0.61) | L3MBTL1MAPTTDP1PPARGPPARD | |
| SCHEMBL11419701 | 0.81 | LPAR1 (0.52) | L3MBTL1MAPTTDP1TP53SMN1; SMN2 | |
| SCHEMBL8672333 | 0.80 | L3MBTL1 (0.60) | L3MBTL1MAPTTDP1PPARGPPARD | |
| SCHEMBL1373729 | 0.80 | KDM4E (0.59) | L3MBTL1MAPTCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL9808263 | 0.80 | L3MBTL1 (0.68) | L3MBTL1MAPTTDP1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |