Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10289213 | 0.83 | REN (0.50) | L3MBTL1MAPTLMNAHPGDALDH1A1 | |
| SCHEMBL91268 | 0.81 | L3MBTL1 (0.69) | L3MBTL1MAPTLMNAHPGDALDH1A1 | |
| SCHEMBL5929490 | 0.81 | MAPT (0.62) | L3MBTL1MAPTLMNAHPGDALDH1A1 | |
| SCHEMBL91269 | 0.81 | SCN8A (0.50) | MAPTLMNAHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL91291 | 0.80 | LMNA (0.41) | L3MBTL1MAPTLMNAHPGDALDH1A1 | |
| SCHEMBL78180 | 0.78 | KDM4E (0.46) | L3MBTL1MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL91185 | 0.78 | L3MBTL1 (0.49) | L3MBTL1MAPTHPGDSMN1; SMN2TDP1 | |
| SCHEMBL8408824 | 0.78 | MAPT (0.49) | L3MBTL1MAPTLMNAHPGDALDH1A1 | |
| SCHEMBL1373729 | 0.77 | KDM4E (0.59) | L3MBTL1MAPTLMNAHPGDALDH1A1 | |
| SCHEMBL11233036 | 0.77 | L3MBTL1 (0.54) | L3MBTL1MAPTHPGDSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |