Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5929490 | 0.82 | MAPT (0.62) | ALDH1A1LMNAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL15869661 | 0.81 | KCNA3 (0.54) | SCN8AALDH1A1 | |
| SCHEMBL5281663 | 0.81 | L3MBTL1 (0.61) | ALDH1A1LMNAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL91273 | 0.81 | L3MBTL1 (0.50) | ALDH1A1LMNAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL1373729 | 0.79 | KDM4E (0.59) | ALDH1A1LMNAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL5294667 | 0.79 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL78591 | 0.77 | ALDH1A1 (0.51) | SCN8AALDH1A1LMNAMAPTHPGD | |
| SCHEMBL3763334 | 0.77 | L3MBTL1 (0.64) | ALDH1A1LMNAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL10289285 | 0.77 | MAPT (0.41) | SCN8AALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL14579984 | 0.77 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |