Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3806966 | 0.81 | TDP1 (0.56) | ALDH1A1MAPTTDP1PLA2G1BL3MBTL1 | |
| SCHEMBL78180 | 0.81 | KDM4E (0.46) | ALDH1A1MAPTTDP1PLA2G1BL3MBTL1 | |
| SCHEMBL3807523 | 0.80 | RAB9A (0.59) | MAPTKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL15869661 | 0.80 | KCNA3 (0.54) | ALDH1A1TDP1NPC1RAB9ASCN8A | |
| SCHEMBL5282382 | 0.80 | TSHR (0.62) | MAPTL3MBTL1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL5288604 | 0.78 | DRD2 (0.55) | ALDH1A1MAPTTDP1PLA2G1BL3MBTL1 | |
| SCHEMBL78449 | 0.78 | SCN8A (0.40) | ALDH1A1MAPTKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL91269 | 0.77 | SCN8A (0.50) | ALDH1A1MAPTHPGDKDM4ESMN1; SMN2 | |
| SCHEMBL22248702 | 0.77 | HRH3 (0.62) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL20234326 | 0.77 | HRH3 (0.61) | ALDH1A1MAPTHPGDKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |