Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 11/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78926 | 0.81 | MAPT (0.38) | MAPTL3MBTL1HPGDMAPK1REN | |
| SCHEMBL10289207 | 0.79 | OXTR (0.35) | L3MBTL1TDP1RXRAGRIN1GRIN2B | |
| SCHEMBL91185 | 0.77 | L3MBTL1 (0.49) | MAPTL3MBTL1HPGDTDP1SMN1; SMN2 | |
| SCHEMBL23335673 | 0.75 | MAPT (0.43) | MAPTL3MBTL1HPGDMAPK1TDP1 | |
| SCHEMBL1750892 | 0.74 | MAPT (0.48) | MAPTL3MBTL1HPGDMAPK1TDP1 | |
| SCHEMBL10289285 | 0.73 | MAPT (0.41) | MAPTSMN1; SMN2HTR1AKDM4EALDH1A1 | |
| SCHEMBL10289208 | 0.72 | L3MBTL1 (0.49) | MAPTL3MBTL1HPGDMAPK1TDP1 | |
| SCHEMBL12504658 | 0.71 | LMNA (0.39) | MAPTL3MBTL1HPGDMAPK1REN | |
| SCHEMBL3660700 | 0.71 | KDM4E (0.50) | MAPTL3MBTL1HPGDMAPK1REN | |
| SCHEMBL13538240 | 0.71 | KDM4E (0.45) | MAPTL3MBTL1HPGDMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |