Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 7/20 | 0.45 |
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | PPIF | P30405 | 1/20 | 0.40 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9127446 | 0.93 | SGMS2 (0.46) | PPIASGMS2SIGMAR1PPIFSMN1; SMN2 | |
| SCHEMBL9126615 | 0.92 | PPIA (0.48) | PPIASGMS2SIGMAR1PPIFSGMS1 | |
| SCHEMBL9124036 | 0.89 | PPIF (0.48) | PPIASGMS2SIGMAR1PPIFALDH1A1 | |
| SCHEMBL9124960 | 0.88 | PPIA (0.47) | PPIASGMS2SIGMAR1PPIFSGMS1 | |
| SCHEMBL9129022 | 0.87 | SGMS2 (0.46) | PPIASGMS2PPIFSMN1; SMN2ALDH1A1 | |
| SCHEMBL9125354 | 0.86 | SGMS2 (0.46) | PPIASGMS2SIGMAR1PPIFSGMS1 | |
| SCHEMBL9128712 | 0.86 | PPIA (0.43) | PPIASGMS2SIGMAR1PPIFALDH1A1 | |
| SCHEMBL9125077 | 0.85 | PPIA (0.62) | PPIAPPIF | |
| SCHEMBL9125102 | 0.85 | PPIA (0.42) | PPIASGMS2SIGMAR1PPIFSMN1; SMN2 | |
| SCHEMBL9126733 | 0.85 | SGMS2 (0.48) | PPIASGMS2PPIFSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5409943-A | [(alkoxy)pyridinyl]amine compounds which are useful in the treatment of gastrointestinal disorders | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1995-04-25 | — | — | US | disclosed |
| EP-0625143-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015055-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | disclosed |