Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 15/20 | 0.62 |
| ▸ | PPIF | P30405 | 2/20 | 0.48 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9125087 | 0.95 | PPIA (0.59) | PPIAPPIFC5AR1PLAU | |
| SCHEMBL2783284 | 0.92 | PPIA (0.58) | PPIAPPIFLTA4HMAPK14 | |
| SCHEMBL9122341 | 0.90 | PPIA (0.51) | PPIAPPIFC5AR1 | |
| SCHEMBL9124791 | 0.89 | NPC1 (0.51) | PPIAPPIFC5AR1 | |
| SCHEMBL9127376 | 0.88 | PPIA (0.53) | PPIAPPIF | |
| SCHEMBL9124960 | 0.87 | PPIA (0.47) | PPIAPPIF | |
| SCHEMBL9125727 | 0.86 | PPIA (0.56) | PPIAPPIF | |
| SCHEMBL9126116 | 0.86 | PPIA (0.64) | PPIAPPIFLTA4HMAPK14 | |
| SCHEMBL9127905 | 0.85 | PPIA (0.45) | PPIAPPIF | |
| SCHEMBL9126127 | 0.85 | PPIA (0.45) | PPIAPPIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5409943-A | [(alkoxy)pyridinyl]amine compounds which are useful in the treatment of gastrointestinal disorders | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1995-04-25 | — | — | US | disclosed |
| EP-0625143-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015055-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | disclosed |