Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9134820 | 0.95 | KDM4E (0.45) | DRD2HTR1AHTR2AKDM4E | |
| SCHEMBL9131769 | 0.89 | DRD2 (0.44) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL11668436 | 0.88 | KMT2A (0.39) | — | |
| SCHEMBL9129583 | 0.88 | HTR1A (0.51) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL11674004 | 0.86 | SIGMAR1 (0.42) | SIGMAR1DRD2DRD3HTR1ATMEM97 | |
| SCHEMBL9133615 | 0.85 | SIGMAR1 (0.47) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL11072336 | 0.84 | PARP1 (0.42) | SIGMAR1HTR1AKDM4E | |
| SCHEMBL10840660 | 0.83 | HTR1A (0.43) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL10749348 | 0.83 | KDM4E (0.47) | DRD2DRD3HTR1AHTR2ADRD4 | |
| SCHEMBL11224396 | 0.79 | SLC6A4 (0.41) | SIGMAR1DRD3HTR1AHTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992018089-A2 | USE OF STEROIDAL AND NON-STEROIDAL AMINES TO SENSITIZE MULTIDRUG-RESISTANT CELLS | THE UPJOHN COMPANY (US) | 1992-10-29 | — | — | WO | claimed |
| US-4179510-A | ISOCHROMANS AND 2-BENZOXEPINS | THE UPJOHN COMPANY (US) | 1979-12-18 | — | — | US | claimed |
| US-5436337-A | Anticarcinogenic agents | THE UPJOHN COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0579754-A1 | USE OF AMINES TO SENSITIZE MULTIDRUG-RESISTANT CELLS | THE UPJOHN COMPANY (US) | 1994-01-26 | — | — | EP | disclosed |
| WO-1992018089-A2 | USE OF STEROIDAL AND NON-STEROIDAL AMINES TO SENSITIZE MULTIDRUG-RESISTANT CELLS | THE UPJOHN COMPANY (US) | 1992-10-29 | — | — | WO | disclosed |
| US-4247553-A | HYPOTENSIVE AGENTS, ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1981-01-27 | — | — | US | disclosed |