Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | HNF4A | P41235 | 1/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1893853 | 0.83 | ALDH1A1 (0.64) | USP2TP53ALDH1A1ALOX15PTPN1 | |
| SCHEMBL31519376 | 0.83 | ALDH1A1 (0.64) | USP2TP53ALDH1A1ALOX15PTPN1 | |
| SCHEMBL22675387 | 0.79 | USP2 (0.55) | USP2TP53FOLH1ALDH1A1ALOX15 | |
| SCHEMBL1787541 | 0.77 | USP2 (0.69) | USP2TP53ALDH1A1ALOX15APEX1 | |
| SCHEMBL12820020 | 0.76 | USP2 (0.59) | USP2TP53FOLH1ALDH1A1ALOX15 | |
| SCHEMBL9409754 | 0.75 | PTPN1 (0.65) | ALDH1A1ALOX15PTPN1GSK3BKMT2A | |
| SCHEMBL1689462 | 0.74 | FOLH1 (0.54) | USP2TP53FOLH1ALDH1A1ALOX15 | |
| SCHEMBL8880348 | 0.74 | HPGDS (0.54) | USP2TP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL7663868 | 0.73 | USP2 (0.64) | USP2TP53ALDH1A1ALOX15KMT2A | |
| SCHEMBL7811204 | 0.73 | TP53 (0.64) | USP2TP53ALDH1A1ALOX15APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5438063-A | Hypotensive agents, cardiac insufficiency, increased intraocular pressure, and CNS disorders | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-08-01 | — | — | US | disclosed |