Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9131309 | 0.94 | HTR1A (0.51) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9134836 | 0.94 | DRD2 (0.52) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9132141 | 0.93 | DRD2 (0.53) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9130405 | 0.90 | HTR2A (0.38) | — | |
| SCHEMBL9131958 | 0.87 | HTR1A (0.56) | HPGDADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL9130474 | 0.86 | HTR1A (0.57) | HPGDADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL9134839 | 0.84 | ADRA1D (0.42) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9131313 | 0.84 | HTR1A (0.42) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9132145 | 0.83 | HTR1A (0.42) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9131992 | 0.83 | HTR1A (0.51) | HTR1ADRD2CA12CA9DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5453437-A | 1,3-disubstituted pyrrolidines | BAYER AKTIENGESELLSCHAFT (DE) | 1995-09-26 | — | — | US | disclosed |
| US-5274097-A | A 1-N-heterocyclic alkylene-3-carbo or heterocyclic ring oxypyrrolidine derivative | BAYER AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | disclosed |
| EP-0338331-B1 | 1,3 DISUBSTITUTED PYRROLIDINES | BAYER AG (DE) | 1992-10-21 | — | — | EP | disclosed |
| US-5037841-A | For treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1991-08-06 | — | — | US | disclosed |
| EP-0338331-A1 | 1,3 Disubstituted Pyrrolidines | BAYER AG (DE) | 1989-10-25 | — | — | EP | disclosed |