SCHEMBL9130757

SCHEMBL9130757

COC(OC)c1cnn(-c2ccccc2Cl)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.38
MTOR P42345 1/20 0.38
NOTUM Q6P988 1/20 0.37
MGLL Q99685 1/20 0.34
PTGS2 P35354 1/20 0.34
AVPR2 P30518 1/20 0.34
AVPR1A P37288 1/20 0.34
PARP1 P09874 1/20 0.32
ADORA3 P0DMS8 1/20 0.32
PKM P14618 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
KCNN4 O15554 1/20 0.32
GAA P10253 2/20 0.31
DRD4 P21917 1/20 0.31
DRD3 P35462 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
CDK1 P06493 1/20 0.31
CDK4 P11802 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17066201 0.83 ALDH1A1 (0.41) BCHEMTORNOTUMMGLLPTGS2
SCHEMBL9132695 0.78 GAA (0.49) ALDH1A1SMN1; SMN2GAADRD4DRD3
SCHEMBL27909633 0.76 BCHE (0.41) BCHEMTORNOTUMPKMALDH1A1
SCHEMBL9131784 0.75 MEN1 (0.41) NOTUMDRD4DRD3RXRAGRIN1
SCHEMBL18933859 0.74 RXRA (0.35) ALDH1A1RXRAGRIN1GRIN2B
SCHEMBL9131851 0.74 TDO2 (0.46) BCHEMTORNOTUMMGLLPTGS2
SCHEMBL9133346 0.74 KDM5B (0.43) NOTUMMGLLPARP1RXRAGRIN1
SCHEMBL6271350 0.73 BCHE (0.46) BCHEMTORNOTUMMGLLAVPR2
SCHEMBL12912131 0.71 L3MBTL1 (0.36) BCHENOTUMMGLLPARP1ADORA3
SCHEMBL18394018 0.70 BCHE (0.44) BCHEMTORNOTUMMGLLPARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0581181-B1 Process for the preparation of 4-dialkoxymetylpyrazoles BASF AG (DE) 1995-12-06 EP disclosed
US-5464508-A Preparation of 4-dialkoxymethylpyrazoles BASF AKTIENGESELLSCHAFT (DE) 1995-11-07 US disclosed
EP-0581181-A1 Process for the preparation of 4-dialkoxymetylpyrazoles BASF Aktiengesellschaft (DE) 1994-02-02 EP disclosed