Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 7/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9129660 | 0.88 | OPRK1 (0.48) | OPRK1 | |
| SCHEMBL9129888 | 0.85 | OPRK1 (0.46) | OPRK1OPRD1NPC1CYP1A2CYP3A4 | |
| SCHEMBL9126782 | 0.84 | OPRK1 (0.45) | OPRK1OPRD1NPC1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9803205 | 0.82 | OPRK1 (0.67) | OPRK1OPRD1NPC1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL10690631 | 0.82 | OPRK1 (0.67) | OPRK1OPRD1NPC1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL10691626 | 0.82 | OPRK1 (0.67) | OPRK1OPRD1NPC1CYP1A2CYP3A4 | |
| SCHEMBL9130785 | 0.79 | PARP1 (0.46) | OPRK1NPC1DRD4 | |
| SCHEMBL9131226 | 0.79 | OPRD1 (0.71) | OPRK1OPRD1 | |
| SCHEMBL9130848 | 0.74 | OPRK1 (0.45) | OPRK1KCNH2 | |
| SCHEMBL9129777 | 0.73 | OPRK1 (0.45) | OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5472961-A | Acetamides | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-12-05 | — | — | US | disclosed |
| EP-0670318-A2 | Acetamides with analgesic and neuroprotective activity | MERCK PATENT GmbH (DE) | 1995-09-06 | — | — | EP | disclosed |