Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chloroform SCHEMBL27284102 | 0.88 | TSHR (0.35) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Acetone SCHEMBL3715272 | 0.87 | LMNA (0.46) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Acetone SCHEMBL8644179 | 0.85 | CHRM2 (0.41) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Acetone SCHEMBL2009017 | 0.84 | CHRM2 (0.44) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Chloroform SCHEMBL83188 | 0.84 | CYP2C9 (0.32) | ALDH1A1TDP1CYP2C9POLB | |
| Acetone SCHEMBL11644767 | 0.84 | CHRM2 (0.44) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Acetone SCHEMBL27728650 | 0.84 | CHRM2 (0.44) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Chloroform SCHEMBL378302 | 0.84 | LMNA (0.33) | LMNA | |
| SCHEMBL3640654 | 0.81 | CHRM2 (0.42) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Chloroform SCHEMBL537028 | 0.81 | ALDH1A1 (0.40) | ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660824-A1 | 1,2 DIHYDRO-3-H-DIBENZ(de,h) ISOQUINOLINE 1,3 DIONE AND THEIR USE AS ANTICANCER AGENTS | RESEARCH CORPORATION TECHNOLOGIES (US) | 1995-07-05 | — | — | EP | disclosed |
| US-5380722-A | Antiarrhythmia agents | ROUSSEL-UCLAF (FR) | 1995-01-10 | — | — | US | disclosed |
| WO-1994006771-A9 | 1,2 DIHYDRO-3-H-DIBENZ(de,h) ISOQUINOLINE 1,3 DIONE AND THEIR USE AS ANTICANCER AGENTS | — | 1994-06-09 | — | — | WO | disclosed |
| WO-1994006771-A1 | 1,2 DIHYDRO-3-H-DIBENZ(de,h) ISOQUINOLINE 1,3 DIONE AND THEIR USE AS ANTICANCER AGENTS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1994-03-31 | — | — | WO | disclosed |
| US-5084455-A | Antiarrhythmia agents for mammals | ROUSSEL UCLAF (FR) | 1992-01-28 | — | — | US | disclosed |
| US-4908367-A | Antiarrythmic agents | Uclaf, Roussel (FR) | 1990-03-13 | — | — | US | disclosed |
| US-4853408-A | 4-phenylpropyl-indoles having antiarythmic activity | ROUSSEL UCLAF (FR) | 1989-08-01 | — | — | US | disclosed |
| US-4808609-A | Amino-(hydroxy)alkoxy-4-phenylpropyl indoles having antiarrythmic activity | ROUSSEL UCLAF (FR) | 1989-02-28 | — | — | US | disclosed |
| US-4791109-A | Novel indole carboxamides | ROUSSEL UCLAF (FR) | 1988-12-13 | — | — | US | disclosed |
| US-4737505-A | Analgesic 4-substituted indoles | ROUSSEL UCLAF (FR) | 1988-04-12 | — | — | US | disclosed |
| US-4332808-A | Dopaminergically stimulating 4-substituted indoles | ROUSSEL UCLAF (FR) | 1982-06-01 | — | — | US | disclosed |
| US-4324790-A | NEUROLEPTIC, ANTIEMETIC | ROUSSEL UCLAF (FR) | 1982-04-13 | — | — | US | disclosed |
| US-4278677-A | Tetrahydropyridinyl indoles | ROUSSEL UCLAF (FR) | 1981-07-14 | — | — | US | disclosed |
| US-4218375-A | SEDATIVES, ANTIHISTAMINES | ROUSSEL UCLAF (FR) | 1980-08-19 | — | — | US | disclosed |
| US-4213989-A | 3-TRIFLUOROMETHYL GROUP ON PHENYL | ROUSSEL UCLAF (FR) | 1980-07-22 | — | — | US | disclosed |
| US-3979515-A | THYMOANALEPTIC ACTIVITY | ROUSSEL-UCLAF (FR) | 1976-09-07 | — | — | US | disclosed |
| US-3957757-A | THYMOANALEPTICS | ROUSSEL-UCLAF (FR) | 1976-05-18 | — | — | US | disclosed |
| US-3953453-A | ANTIMALARIAL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1976-04-27 | — | — | US | disclosed |
| US-3950527-A | SEDATIVES | ROUSSEL-UCLAF (FR) | 1976-04-13 | — | — | US | disclosed |
| US-3931151-A | ANTIDEPRESSANT, NEURO-SEDATIVE | ROUSSEL-UCLAF (FR) | 1976-01-06 | — | — | US | disclosed |