Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | P4HB | P07237 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1751401 | 0.82 | REN (0.43) | TSHRSMN1; SMN2RENKDM4EKCNH2 | |
| SCHEMBL78604 | 0.81 | TSHR (0.38) | TSHRSMN1; SMN2RENKDM4EALDH1A1 | |
| SCHEMBL4682925 | 0.80 | REN (0.56) | RENKCNH2 | |
| SCHEMBL91334 | 0.78 | PYGL (0.49) | L3MBTL1RENALDH1A1AKT1KCNH2 | |
| SCHEMBL91283 | 0.77 | GPR84 (0.44) | TSHRSMN1; SMN2L3MBTL1RENKDM4E | |
| SCHEMBL10885864 | 0.76 | CYP1A2 (0.50) | SMN1; SMN2L3MBTL1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL1751233 | 0.76 | REN (0.51) | RENKCNH2 | |
| SCHEMBL11650876 | 0.73 | NPC1 (0.53) | SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL20234272 | 0.73 | CHRM2 (0.43) | SMN1; SMN2L3MBTL1EPHX1NPC1RAB9A | |
| SCHEMBL10889252 | 0.72 | LTA4H (0.44) | SMN1; SMN2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |