Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP7 | P09237 | 2/20 | 0.48 |
| ▸ | MMP14 | P50281 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PRNP | P04156 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL2279843 | 0.84 | MMP2 (0.65) | HSD11B1POLBMMP2MMP7MMP14 | |
| SCHEMBL2805655 | 0.81 | ALDH1A1 (0.66) | HSD11B1POLBALDH1A1TP53HTT | |
| SCHEMBL5467897 | 0.79 | HSD11B1 (0.53) | HSD11B1POLBALDH1A1TP53HTT | |
| Hydrochloric Acid SCHEMBL19066539 | 0.79 | ALDH1A1 (0.63) | HSD11B1POLBALDH1A1TP53HTT | |
| SCHEMBL27577204 | 0.79 | HSD11B1 (0.49) | HSD11B1POLBALDH1A1TP53HTT | |
| SCHEMBL7427351 | 0.78 | POLB (0.59) | HSD11B1POLBALDH1A1TP53HTT | |
| SCHEMBL2279847 | 0.77 | HSD11B1 (0.47) | HSD11B1POLBALDH1A1MMP2MMP7 | |
| SCHEMBL6129032 | 0.77 | HSD11B1 (0.60) | HSD11B1POLBALDH1A1TP53HTT | |
| SCHEMBL6428540 | 0.76 | POLB (0.68) | HSD11B1POLBALDH1A1TP53HTT | |
| SCHEMBL6550260 | 0.76 | POLB (0.68) | HSD11B1POLBALDH1A1TP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5472967-A | Angiotensin II antagonists | SYNTHELABO (FR) | 1995-12-05 | — | — | US | disclosed |
| EP-0500409-A1 | 4-Pyrimidinone derivatives, their preparation and their application in therapy | SYNTHELABO (FR) | 1992-08-26 | — | — | EP | disclosed |