Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6039798 | 0.85 | IDO1 (0.47) | SLC6A4HTR6IDO1IMPDH2IMPDH1 | |
| SCHEMBL13323651 | 0.81 | HTR6 (0.63) | SLC6A4HTR6IDO1MAP3K14IMPDH2 | |
| SCHEMBL20846147 | 0.80 | HTR6 (0.52) | SLC6A4HTR6MAP3K14SLC6A2SLC6A3 | |
| SCHEMBL401146 | 0.78 | DRD2 (0.49) | SLC6A4HTR6IDO1MAP3K14IMPDH2 | |
| SCHEMBL22359655 | 0.78 | SLC6A4 (0.49) | SLC6A4HTR6IDO1MAP3K14IMPDH2 | |
| SCHEMBL14142175 | 0.78 | AR (0.51) | SLC6A4HTR6IDO1MAP3K14IMPDH2 | |
| SCHEMBL733659 | 0.78 | SLC6A4 (0.52) | SLC6A4HTR6IDO1HTR1ADRD1 | |
| SCHEMBL3627983 | 0.78 | MAP3K14 (0.54) | SLC6A4HTR6IDO1MAP3K14IMPDH2 | |
| SCHEMBL15585966 | 0.78 | SLC6A4 (0.49) | SLC6A4HTR6IDO1MAP3K14IMPDH2 | |
| SCHEMBL29994158 | 0.78 | SLC6A4 (0.52) | SLC6A4HTR6IDO1HTR1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3730489-A1 | HETEROARYL COMPOUNDS AS AGROCHEMICAL FUNGICIDES | BASF SE (DE) | 2020-10-28 | — | — | EP | disclosed |
| WO-2019057660-A1 | INDOLE AND AZAINDOLE COMPOUNDS WITH SUBSTITUTED 6-MEMBERED ARYL AND HETEROARYL RINGS AS AGROCHEMICAL FUNGICIDES | BASF SE (DE) | 2019-03-28 | — | — | WO | disclosed |
| WO-2019057660-A1 | INDOLE AND AZAINDOLE COMPOUNDS WITH SUBSTITUTED 6-MEMBERED ARYL AND HETEROARYL RINGS AS AGROCHEMICAL FUNGICIDES | BASF SE (DE) | 2019-03-28 | — | — | WO | disclosed |
| US-9321756-B2 | Azole compounds as PIM inhibitors | AMGEN INC. (US) | 2016-04-26 | — | — | US | disclosed |
| US-9321756-B2 | Azole compounds as PIM inhibitors | AMGEN INC. (US) | 2016-04-26 | — | — | US | disclosed |
| US-9173869-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-8852937-B2 | Small organic molecule regulators of cell proliferation | CURIS, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-20140187553-A1 | Azole Compounds as PIM Inhibitors | AMGEM INC. (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140187553-A1 | Azole Compounds as PIM Inhibitors | AMGEM INC. (US) | 2014-07-03 | — | — | US | disclosed |
| EP-2688886-A1 | AZOLE COMPOUNDS AS PIM INHIBITORS | Amgen Inc. (US) | 2014-01-29 | — | — | EP | disclosed |
| US-20110077256-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | GUICHERIT OIVIN M | 2011-03-31 | — | — | US | disclosed |
| US-20100190775-A1 | PYRIMIDODIAZEPINONE DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD (JP) | 2010-07-29 | — | — | US | disclosed |
| EP-2163554-A1 | PYRIMIDODIAZEPINONE DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2010-03-17 | — | — | EP | disclosed |
| EP-1272168-B2 | SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION | CURIS INC (US) | 2009-10-28 | — | — | EP | disclosed |
| US-20080207740-A1 | tert-Butyl {4-[(4'-cyano-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate; hedgehog pathway agonists; to modulate proliferation or differentiation in a cell or tissue in vivo or vitro; alopecia; angiogenesis; wound healing; alzheimer's disease; to inhibit aging effects on skin | CURIS, INC. (US) | 2008-08-28 | — | — | US | disclosed |
| US-20070021493-A1 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2007-01-25 | — | — | US | disclosed |
| US-7105516-B2 | Compounds for the treatment of premature ejaculation | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-09-12 | — | — | US | disclosed |
| US-20050070578-A1 | Small organic molecule regulators of cell proliferation | CURIS, INC. | 2005-03-31 | — | — | US | disclosed |
| WO-2004026237-A2 | COMPOUNDS FOR THE TREATMENT OF PREMATURE EJACULATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |
| US-20040063768-A1 | Compounds for the treatment of premature ejaculation | BRISTOL-MYERS SQUIBB COMPANY | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063768-A1 | Compounds for the treatment of premature ejaculation | HTR5A, SLC18A2, CYP17A1 | SLC6A4 12/4885HTR6 9/4885IDO1 2916/4885 |
| US-20070021493-A1 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | SHH, SMO, GLI1 | SLC6A4 4702/4885HTR6 2289/4885IDO1 4229/4885 |
| US-20080207740-A1 | tert-Butyl {4-[(4'-cyano-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate; hedgehog pathway agonists; to modulate proliferation or differentiation in a cell or tissue in vivo or vitro; alopecia; angiogenesis; wound healing; alzheimer's disease; to inhibit aging effects on skin | SHH, GLI1, SMO | SLC6A4 4323/4885HTR6 923/4885IDO1 1037/4885 |
| US-20100190775-A1 | PYRIMIDODIAZEPINONE DERIVATIVE | KCNJ1, KCNJ11, ADRA1D | SLC6A4 194/4885HTR6 386/4885IDO1 1557/4885 |
| US-20110077256-A1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | SHH, SMO, GLI1 | SLC6A4 4702/4885HTR6 2289/4885IDO1 4229/4885 |
| US-20140187553-A1 | Azole Compounds as PIM Inhibitors | PIM1, PIM3, PIM2 | SLC6A4 4526/4885HTR6 4688/4885IDO1 212/4885 |
| US-20050070578-A1 | Small organic molecule regulators of cell proliferation | GLI1, SHH, SMO | SLC6A4 4594/4885HTR6 1759/4885IDO1 2423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.