Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 3/20 | 0.39 |
| ▸ | CES1 | P23141 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9137695 | 1.00 | CYP3A4 (0.43) | CYP3A4TSHRMAPK1ATML3MBTL1 | |
| SCHEMBL1085516 | 0.80 | KMT2A (0.40) | CYP3A4TSHRATMLMNAADRA2A | |
| SCHEMBL1085514 | 0.80 | KMT2A (0.40) | CYP3A4TSHRATMLMNAADRA2A | |
| SCHEMBL24769300 | 0.80 | ESR1 (0.44) | CYP3A4TSHRMAPK1ATML3MBTL1 | |
| SCHEMBL9132542 | 0.78 | TSHR (0.44) | TSHRADRA2ADRD1SLC6A2SLC6A4 | |
| SCHEMBL9132551 | 0.78 | TSHR (0.44) | TSHRADRA2ADRD1SLC6A2SLC6A4 | |
| SCHEMBL9133338 | 0.78 | ALDH1A1 (0.50) | TSHRMAPK1LMNAALDH1A1MAPT | |
| SCHEMBL9133343 | 0.78 | ALDH1A1 (0.50) | TSHRMAPK1LMNAALDH1A1MAPT | |
| SCHEMBL6560344 | 0.76 | TSHR (0.38) | CYP3A4TSHRMAPK1ATML3MBTL1 | |
| SCHEMBL15944877 | 0.75 | CA1 (0.50) | TSHRL3MBTL1LMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10342781-B2 | Diazole amides | CHEMOCENTRYX, INC. (US) | 2019-07-09 | — | — | US | disclosed |
| US-10342781-B2 | Diazole amides | CHEMOCENTRYX, INC. (US) | 2019-07-09 | — | — | US | disclosed |
| US-20180071257-A1 | DIAZOLE AMIDES | CHEMOCENTRYX, INC. | 2018-03-15 | — | — | US | disclosed |
| US-20180071257-A1 | DIAZOLE AMIDES | CHEMOCENTRYX, INC. | 2018-03-15 | — | — | US | disclosed |
| US-20180071257-A1 | DIAZOLE AMIDES | CHEMOCENTRYX, INC. | 2018-03-15 | — | — | US | disclosed |
| EP-2935227-B1 | DIAZOLE AMIDES AS CCR1 RECEPTOR ANTAGONISTS | CHEMOCENTRYX INC (US) | 2017-09-13 | — | — | EP | disclosed |
| EP-2935227-B1 | DIAZOLE AMIDES AS CCR1 RECEPTOR ANTAGONISTS | CHEMOCENTRYX INC (US) | 2017-09-13 | — | — | EP | disclosed |
| US-9750722-B2 | Diazole amides | CHEMOCENTRYX, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-9750722-B2 | Diazole amides | CHEMOCENTRYX, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-9750722-B2 | Diazole amides | CHEMOCENTRYX, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-9169248-B2 | Diazole amides | CHEMOCENTRYX, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-9169248-B2 | Diazole amides | CHEMOCENTRYX, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-9169248-B2 | Diazole amides | CHEMOCENTRYX, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-20140228579-A1 | METHOD FOR THE CATALYTIC REDUCTION OF ACID CHLORIDES AND IMIDOYL CHLORIDES | Brock Unviersity (CA) | 2014-08-14 | — | — | US | disclosed |
| US-20140228579-A1 | METHOD FOR THE CATALYTIC REDUCTION OF ACID CHLORIDES AND IMIDOYL CHLORIDES | Brock Unviersity (CA) | 2014-08-14 | — | — | US | disclosed |
| US-20140179733-A1 | DIAZOLE AMIDES | CHEMOCENTRYX, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| US-20140179733-A1 | DIAZOLE AMIDES | CHEMOCENTRYX, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| WO-2014100735-A2 | DIAZOLE AMIDES | CHEMOCENTRYX, INC. (US) | 2014-06-26 | — | — | WO | disclosed |
| US-20140179733-A1 | DIAZOLE AMIDES | CHEMOCENTRYX, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| US-5378702-A | Thiadizinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180071257-A1 | DIAZOLE AMIDES | CCR1, CCRL2, CCR4 | CYP3A4 3192/4885TSHR 3054/4885MAPK1 2106/4885 |
| US-10342781-B2 | Diazole amides | CCR1, CCRL2, CCR4 | CYP3A4 3192/4885TSHR 3054/4885MAPK1 2106/4885 |
| US-20140228579-A1 | METHOD FOR THE CATALYTIC REDUCTION OF ACID CHLORIDES AND IMIDOYL CHLORIDES | CA6, RUVBL2, HACL2 | CYP3A4 3310/4885TSHR 3534/4885MAPK1 4412/4885 |
| US-20140179733-A1 | DIAZOLE AMIDES | CCR1, CCRL2, CCR4 | CYP3A4 3192/4885TSHR 3054/4885MAPK1 2106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.