Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.55 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.55 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA5A | P35218 | 1/20 | 0.54 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13454572 | 0.86 | ALDH1A1 (0.59) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL11637300 | 0.85 | GPR27 (0.63) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL2701214 | 0.83 | LMNA (0.67) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL882781 | 0.81 | NPC1 (0.75) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8060238 | 0.81 | NPC1 (0.75) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8665327 | 0.81 | CA1 (0.74) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL882734 | 0.80 | KMT2A (0.80) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1380321 | 0.78 | MAPT (0.53) | RAB9AKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5569673 | 0.78 | NPC1 (0.75) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL882776 | 0.78 | NPC1 (0.75) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5420292-A | Biphenyl-tetrazole intermediate compounds | ZENECA LIMITED (GB) | 1995-05-30 | — | — | US | disclosed |
| US-5294716-A | Chemical process for making angiotesin II antagonist compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-03-15 | — | — | US | disclosed |
| EP-0495626-A1 | Process for the preparation of tetrazole derivatives | ZENECA LIMITED (GB) | 1992-07-22 | — | — | EP | disclosed |