Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NPR1 | P16066 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9146876 | 0.83 | CTSD (0.35) | BACE1CTSDMALT1ALDH1A1SRD5A1 | |
| SCHEMBL9147914 | 0.83 | PARP1 (0.34) | TP53MAPTSRD5A1 | |
| SCHEMBL9146937 | 0.82 | ABCC9 (0.36) | BACE1CTSDCYP1A2MALT1MAOB | |
| SCHEMBL9143553 | 0.76 | ABCC9 (0.37) | BACE1CTSDCYP1A2MALT1MAOB | |
| SCHEMBL9147151 | 0.75 | CASP6 (0.38) | TDP1MALT1ALDH1A1MAPTNR3C2 | |
| SCHEMBL27321636 | 0.69 | KMT2A (0.40) | BACE1CTSDPIK3CDPIK3CAPIK3CB | |
| SCHEMBL9146574 | 0.68 | BACE1 (0.35) | BACE1CTSDPIK3CDPIK3CAPIK3CB | |
| SCHEMBL9147618 | 0.66 | BACE1 (0.35) | BACE1CTSDTP53TSHRALDH1A1 | |
| SCHEMBL9146857 | 0.65 | ABCC9 (0.30) | CYP1A2LMNA | |
| SCHEMBL9146859 | 0.65 | ABCC9 (0.30) | CYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5420126-A | Potassium channel activators | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-05-30 | — | — | US | disclosed |
| EP-0432893-A2 | Benzoxazine derivatives, their preparation and pharmaceutical compositions containing them | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1991-06-19 | — | — | EP | disclosed |