Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MTOR | P42345 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | HBB | P68871 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CDA | P32320 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL114650 | 0.89 | LMNA (0.45) | LMNAMTORALDH1A1TP53THRB | |
| SCHEMBL9343755 | 0.87 | LMNA (0.44) | LMNAMTORALDH1A1TP53THRB | |
| Phosphoric Acid SCHEMBL20305093 | 0.85 | LMNA (0.42) | LMNAMTORALDH1A1TP53THRB | |
| Phosphoric Acid SCHEMBL6465085 | 0.85 | LMNA (0.42) | LMNAMTORALDH1A1TP53THRB | |
| SCHEMBL30612476 | 0.79 | EGFR (0.39) | LMNAMTORALDH1A1TP53THRB | |
| SCHEMBL31685308 | 0.76 | LMNA (0.36) | LMNAMTORALDH1A1TP53THRB | |
| SCHEMBL29387992 | 0.75 | LMNA (0.40) | LMNAMTORALDH1A1TP53THRB | |
| SCHEMBL31529987 | 0.74 | LMNA (0.39) | LMNAMTORALDH1A1TP53THRB | |
| SCHEMBL31685168 | 0.74 | ADORA1 (0.42) | — | |
| SCHEMBL20305094 | 0.73 | UMPS (0.51) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0341066-B1 | Immunostimulating guanine derivatives, compositions and methods | SCRIPPS CLINIC RES (US) | 1994-11-09 | — | — | EP | claimed |
| EP-0341066-A2 | Immunostimulating guanine derivatives, compositions and methods | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1989-11-08 | — | — | EP | claimed |
| EP-0341065-A2 | Immunostimulating guanine dervatives, compositions and methods | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1989-11-08 | — | — | EP | claimed |
| WO-2022031057-A1 | CONJUGATE OF FUNCTIONAL DRUG AND TOLL-LIKE RECEPTOR 7 OR 8 AGONIST OF WHICH ACTIVE SITE IS TEMPORARILY INACTIVATED AND USE THEREOF | 성균관대학교산학협력단 | 2022-02-10 | — | — | WO | disclosed |
| US-5476659-A | Killing; particularly lymphocytic leukemia | THE SCRIPPS RESEARCH INSTITUTE (US) | 1995-12-19 | — | — | US | disclosed |
| EP-0341066-B1 | Immunostimulating guanine derivatives, compositions and methods | SCRIPPS CLINIC RES (US) | 1994-11-09 | — | — | EP | disclosed |
| EP-0341065-B1 | Immunostimulating guanine dervatives, compositions and methods | SCRIPPS CLINIC RES (US) | 1994-07-27 | — | — | EP | disclosed |
| WO-1994011003-A1 | CANCEROUS B CELL TREATMENT USING SUBSTITUTED NUCLEOSIDE DERIVATIVES | THE SCRIPPS RESEARCH INSTITUTE (US) | 1994-05-26 | — | — | WO | disclosed |
| US-5166141-A | Antigen specific immunune response by contacting lymphocytes | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1992-11-24 | — | — | US | disclosed |
| US-5136030-A | Immunostimulating guanine derivatives, compositions and methods | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1992-08-04 | — | — | US | disclosed |
| US-5093318-A | Immunostimulating guanosine derivatives and their pharmaceutical compositions | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1992-03-03 | — | — | US | disclosed |
| US-5011828-A | Immunostimulating guanine derivatives, compositions and methods | SCRIPPS CLINIC AND RESEARCH FOUNDATION | 1991-04-30 | — | — | US | disclosed |
| EP-0343945-A2 | Immunostimulating 7-deaza-7-oxa-and 7-deaza-7-thia-analogs of 8-substituted-guanine-9-(1'-beta-d-aldoglycosidyl) derivatives, compositions and methods | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1989-11-29 | — | — | EP | disclosed |
| EP-0341065-A2 | Immunostimulating guanine dervatives, compositions and methods | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1989-11-08 | — | — | EP | disclosed |
| EP-0341066-A2 | Immunostimulating guanine derivatives, compositions and methods | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1989-11-08 | — | — | EP | disclosed |