Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 10/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5729169 | 0.79 | MAPT (0.32) | ALDH1A1KDM4EMAPT | |
| SCHEMBL12410042 | 0.72 | HDAC3 (0.42) | KDM4EHTT | |
| SCHEMBL12410038 | 0.69 | KDM4E (0.36) | ALDH1A1KDM4EGAAHPGDCASP1 | |
| SCHEMBL9466509 | 0.68 | PGR (0.36) | ALDH1A1KDM4EHPGDSMN1; SMN2NPC1 | |
| SCHEMBL544297 | 0.67 | ALDH1A1 (0.60) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL19136630 | 0.67 | PIK3CD (0.42) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL68892 | 0.67 | MAPT (0.69) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL5729584 | 0.66 | ALDH1A1 (0.40) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL27213311 | 0.66 | MAPK1 (0.37) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL27710422 | 0.64 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTMAOBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378713-A | Vasodilators; angina pectoris | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-01-03 | — | — | US | claimed |
| EP-0360621-B1 | Substituted thienopyrans as antihypertensive agents | ORTHO PHARMA CORP (US) | 1994-01-19 | — | — | EP | claimed |
| US-5030736-A | Hypotensive agents, treatment of angina pectoris, vasodilators | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-07-09 | — | — | US | claimed |
| US-4992435-A | Vasodilators | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-02-12 | — | — | US | claimed |
| EP-0360621-A1 | Substituted thienopyrans as antihypertensive agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1990-03-28 | — | — | EP | claimed |
| US-5457212-A | Process for the preparation of enantiomerically pure thienopyran derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-10-10 | — | — | US | disclosed |
| US-5378713-A | Vasodilators; angina pectoris | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-01-03 | — | — | US | disclosed |
| US-5284857-A | For treating cardiovascular disorders, angina | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0360621-B1 | Substituted thienopyrans as antihypertensive agents | ORTHO PHARMA CORP (US) | 1994-01-19 | — | — | EP | disclosed |
| US-5260453-A | Substituted thienopyrans as antihypertensive agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0493048-A1 | The process for the preparation of enantiomerically pure thienopyran derivative | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-07-01 | — | — | EP | disclosed |
| US-5030736-A | Hypotensive agents, treatment of angina pectoris, vasodilators | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-07-09 | — | — | US | disclosed |
| US-4992435-A | Vasodilators | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0360621-A1 | Substituted thienopyrans as antihypertensive agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1990-03-28 | — | — | EP | disclosed |