Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12494327 | 0.76 | KMT2A (0.44) | KDM4EKMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL12410042 | 0.74 | HDAC3 (0.42) | KDM4EHTTATMSIGMAR1HDAC3 | |
| SCHEMBL12409980 | 0.73 | KMT2A (0.51) | KDM4EKMT2AHTTATMHDAC3 | |
| SCHEMBL13791484 | 0.73 | HSD11B1 (0.59) | KDM4EKMT2AHTTATMHDAC3 | |
| SCHEMBL12410062 | 0.73 | EPHX2 (0.53) | SIGMAR1ADRA1DADRA1AADRA1BEPHX2 | |
| SCHEMBL9149481 | 0.69 | ALDH1A1 (0.45) | KDM4EHTTALDH1A1GAAGLA | |
| SCHEMBL12410047 | 0.64 | HSD11B1 (0.32) | KDM4EKMT2AALDH1A1GAA | |
| SCHEMBL12409962 | 0.64 | HSD11B1 (0.55) | KDM4EKMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL12409983 | 0.62 | HRH3 (0.38) | SIGMAR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12410066 | 0.62 | SIGMAR1 (0.33) | KMT2ASIGMAR1ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166124-A1 | TRICYCLIC SPIROCYCLE DERIVATIVES AND METHODS OF USE | MCCORMICK KEVIN D | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166124-A1 | TRICYCLIC SPIROCYCLE DERIVATIVES AND METHODS OF USE | GPR119, TRPV1, NR3C2 | KDM4E 3844/4885KMT2A 4310/4885HTT 2054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.