Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.62 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20585273 | 0.89 | CYP19A1 (0.76) | CYP19A1ACHESIGMAR1CES1LMNA | |
| SCHEMBL15874625 | 0.89 | CYP19A1 (0.76) | CYP19A1ACHESIGMAR1CES1LMNA | |
| SCHEMBL15292027 | 0.89 | CYP19A1 (0.76) | CYP19A1ACHESIGMAR1CES1LMNA | |
| SCHEMBL4810645 | 0.89 | CYP19A1 (0.76) | CYP19A1ACHESIGMAR1CES1LMNA | |
| SCHEMBL12852979 | 0.87 | CYP19A1 (0.56) | CYP19A1CYP2A6MAOAMAOBACHE | |
| SCHEMBL12852999 | 0.80 | GID4 (0.68) | CYP19A1LMNAMAPTDDB1CRBN | |
| SCHEMBL12852997 | 0.78 | CYP19A1 (0.50) | CYP19A1CYP2A6MAOAMAOBACHE | |
| SCHEMBL5077391 | 0.78 | CYP19A1 (0.57) | CYP19A1MAOAMAOBACHESIGMAR1 | |
| SCHEMBL30785363 | 0.78 | ACHE (0.55) | CYP19A1ACHESIGMAR1LMNATP53 | |
| SCHEMBL2345374 | 0.78 | ACHE (0.55) | CYP19A1ACHESIGMAR1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4276188-A1 | METHOD FOR SYNTHESIZING CHIRAL AMINE COMPOUND | Asymchem Laboratories (Tianjin) Co., Ltd. (CN) | 2023-11-15 | — | — | EP | disclosed |
| US-5416118-A | Enzyme inhibitors | SCHERING CORPORATION (US) | 1995-05-16 | — | — | US | disclosed |
| EP-0583346-A1 | BICYCLIC AMIDES AS INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL ACYL TRANSFERASE | SCHERING CORPORATION (US) | 1994-02-23 | — | — | EP | disclosed |
| WO-1992018462-A1 | BICYCLIC AMIDES AS INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL ACYL TRANSFERASE | SCHERING CORPORATION (US) | 1992-10-29 | — | — | WO | disclosed |
| EP-0508425-A1 | Bicyclic amides as inhibitors of acyl-coenzyme a: cholesterol acyl transferase | SCHERING CORPORATION (US) | 1992-10-14 | — | — | EP | disclosed |