SCHEMBL9150286

SCHEMBL9150286

CCCCc1nn(-c2ccccc2)c(COC)c1Cc1ccc(-c2ccccc2C(=O)O)cc1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 1/20 0.54
AGTR2 P50052 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9154093 0.93 AGTR1 (0.52) AGTR1AGTR2
SCHEMBL9155170 0.90 ACHE (0.46) AGTR1AGTR2
SCHEMBL9148754 0.89 AGTR1 (0.56) AGTR1AGTR2
SCHEMBL9154711 0.85 AGTR1 (0.52) AGTR1AGTR2
SCHEMBL9152688 0.84 AGTR1 (0.51) AGTR1AGTR2
SCHEMBL9149242 0.84 AGTR1 (0.51) AGTR1AGTR2
SCHEMBL9154033 0.83 AGTR1 (0.54) AGTR1AGTR2
SCHEMBL9152814 0.83 ACHE (0.46) AGTR1AGTR2
SCHEMBL9842316 0.81 AGTR1 (0.60) AGTR1AGTR2
SCHEMBL9153430 0.81

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5389659-A Hypotensive agents GLAXO GROUP LIMITED (GB) 1995-02-14 US disclosed
WO-1993005025-A1 C-LINKED PYRAZOLE DERIVATIVES GLAXO GROUP LIMITED (GB) 1993-03-18 WO disclosed
EP-0446062-A1 C-Linked pyrazole derivatives GLAXO GROUP LIMITED (GB) 1991-09-11 EP disclosed