Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9150726 | 0.86 | KCNH2 (0.61) | KCNH2APPDRD2HTR6 | |
| SCHEMBL9146788 | 0.85 | KCNH2 (0.64) | KCNH2APPDRD2HTR6 | |
| SCHEMBL9150576 | 0.85 | KCNH2 (0.82) | KCNH2SLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL9153001 | 0.84 | KCNH2 (0.63) | KCNH2APPDRD2HTR6 | |
| SCHEMBL9150686 | 0.83 | KCNH2 (0.58) | KCNH2HTR6HTR1A | |
| SCHEMBL8640342 | 0.82 | KCNH2 (0.81) | KCNH2SLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL9145768 | 0.80 | DRD2 (0.52) | SLC6A4DRD2 | |
| SCHEMBL9149972 | 0.79 | HTR1A (0.51) | HTR1A | |
| SCHEMBL2739092 | 0.78 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL6599893 | 0.78 | KCNH2 (0.74) | KCNH2SLC6A2SLC6A4SLC6A3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5457115-A | Treating anxiety, depression, sleep disorders, migranes, schizophrenia or Parkinson's disease in humans | H. LUNDBECK A/S (DK) | 1995-10-10 | — | — | US | disclosed |
| EP-0465398-B1 | Novel indole derivatives | LUNDBECK & CO AS H (DK) | 1994-12-14 | — | — | EP | disclosed |
| US-5322851-A | Indole derivatives | H. LUNDBECK A/S (DK) | 1994-06-21 | — | — | US | disclosed |
| US-5216001-A | Central nervous system disorders | H. LUNBECK A/S (DK) | 1993-06-01 | — | — | US | disclosed |