Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFSF11 | O14788 | 7/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 7/20 | 0.50 |
| ▸ | TNF | P01375 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR1F | P30939 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | IDE | P14735 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9149259 | 0.87 | TNFSF11 (0.50) | TNFSF11CA2CA9PSEN1PSEN2 | |
| SCHEMBL9153167 | 0.83 | HTR6 (0.57) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL3033927 | 0.78 | HTR6 (0.71) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL351630 | 0.78 | HTR6 (0.57) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL9152262 | 0.78 | KMT2A (0.59) | — | |
| SCHEMBL29169610 | 0.75 | HTR6 (0.57) | CA2CA9HTR6HTR1ADRD2 | |
| SCHEMBL9152646 | 0.75 | IDE (0.43) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL27662543 | 0.75 | PPARG (0.54) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL947245 | 0.74 | HTR6 (0.51) | TNFSF11CA2CA9HTR6HTR1A | |
| SCHEMBL352748 | 0.73 | HTR6 (0.65) | HTR6HTR1ADRD2HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516849-B1 | INDOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5283251-A | Testosterone 5a-reductase inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-02-01 | — | — | US | disclosed |
| EP-0516849-A1 | INDOLE DERIVATIVES. | FUJISAWA PHARMACEUTICAL CO (JP) | 1992-12-09 | — | — | EP | disclosed |
| WO-1991013060-A1 | INDOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-09-05 | — | — | WO | disclosed |