Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9150672 | 1.00 | ACHE (0.60) | ACHEBCHE | |
| SCHEMBL9151835 | 0.95 | ACHE (0.66) | ACHEBCHE | |
| Fumaric Acid SCHEMBL9149192 | 0.87 | BCHE (0.50) | ACHEBCHE | |
| Fumaric Acid SCHEMBL9149189 | 0.87 | BCHE (0.50) | ACHEBCHE | |
| Fumaric Acid SCHEMBL9151893 | 0.83 | ACHE (0.60) | ACHEBCHE | |
| Fumaric Acid SCHEMBL9151888 | 0.83 | ACHE (0.60) | ACHEBCHE | |
| SCHEMBL9149764 | 0.82 | BCHE (0.55) | ACHEBCHE | |
| SCHEMBL9248134 | 0.78 | ACHE (0.66) | ACHEBCHE | |
| SCHEMBL9245381 | 0.78 | ACHE (0.66) | ACHEBCHE | |
| Hydrochloric Acid SCHEMBL9149311 | 0.77 | ACHE (0.65) | ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434179-A | Enzyme inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-07-18 | — | — | US | claimed |
| EP-0401715-B1 | Aminoketone compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-01-25 | — | — | EP | claimed |
| EP-0401715-A2 | Aminoketone compounds | Takeda Chemical Industries, Ltd. (JP) | 1990-12-12 | — | — | EP | claimed |
| US-5434179-A | Enzyme inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-07-18 | — | — | US | disclosed |
| EP-0401715-B1 | Aminoketone compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| EP-0401715-A2 | Aminoketone compounds | Takeda Chemical Industries, Ltd. (JP) | 1990-12-12 | — | — | EP | disclosed |